Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
18
|
| pubmed:dateCreated |
1978-12-2
|
| pubmed:abstractText |
The serum concentration of 1,25-dihydroxylvitamin D (1,25-[OH]2D) in normal children and in children with inherited diseases of bone was compared by use of a competitive binding assay. Observed values were: in 12 normal children and adolescents, 37.1 +/- 1.9 pg per milliliter (mean +/- S.D.); in 14 patients with X-linked hypophosphatemic rickets treated with vitamin D2 and phosphate supplements, 15.6 +/- 7.8 (P less than 0.01 versus control); in six patients with autosomal recessive vitamin D dependency treated with vitamin D2, 9.5 +/- 2.9 (P less than 0.01 versus control); and in four untreated patients with autosomal dominant hypophosphatemic (non-rachitic) bone disease, 30.2 +/- 6.3 (not significantly different from the controls). The difference in bone disease between X-linked hypophosphatemia (severe) and hypophosphatemic bone disease (mild) at comparable low serum levels of phosphate implies that 1,25-(OH)2D and phosphate may have independent roles in the pathogenesis of defective bone mineralization.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0028-4793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
299
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
976-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:308618-Adolescent,
pubmed-meshheading:308618-Adult,
pubmed-meshheading:308618-Age Factors,
pubmed-meshheading:308618-Binding, Competitive,
pubmed-meshheading:308618-Bone Diseases,
pubmed-meshheading:308618-Child,
pubmed-meshheading:308618-Child, Preschool,
pubmed-meshheading:308618-Dihydroxycholecalciferols,
pubmed-meshheading:308618-Ergocalciferols,
pubmed-meshheading:308618-Female,
pubmed-meshheading:308618-Genes, Dominant,
pubmed-meshheading:308618-Genes, Recessive,
pubmed-meshheading:308618-Humans,
pubmed-meshheading:308618-Hydroxycholecalciferols,
pubmed-meshheading:308618-Hypophosphatemia, Familial,
pubmed-meshheading:308618-Male,
pubmed-meshheading:308618-Phosphates,
pubmed-meshheading:308618-Rickets,
pubmed-meshheading:308618-X Chromosome
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Serum 1,25-dihydroxyvitamin D levels in normal subjects and in patients with hereditary rickets or bone disease.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|