Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1978-11-29
pubmed:abstractText
Altered blood levels of T and B lymphocytes were found in the first half of human pregnancy. A total of twenty-two women were tested, using direct or indirect rosetting assays or the fluorescence-activated cell sorter, to determine the levels of peripheral blood T and B cells. In all cases, an inversion of T- and B-cell levels was observed, i.e. T-cell levels were decreased and B-cell levels (as measured by the presence of surface immunoglobulin or the presence of B-cell surface antigens) were increased. This inversion was exhibited as early as 1 week post-implantation. Lymphocytes from two fo the women were also examined for stimulation with phytohaemagglutinin (PHA) and pokeweed mitogen (PWM) at intervals during gestation, and the amount of [3H]thymidine uptake was compared to that of two non-pregnant women tested at each interval. The values obtained for the pregnant women with PHA were markedly lower, and with pokeweed mitogen slightly lower, than those of non-pregnant controls. However, the PHA and PWM values in the pregnant women returned to levels similar to those of the nonpregnant women shortly after the T- and B-cell levels returned to normal. Thus the decrease in the response of the lymphocytes to mitogens during early pregnancy appears to parallel the numerical deficiency of T cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-1081651, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-1097574, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-1125143, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-123259, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-13494475, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-13716750, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-137269, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-13955636, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-300152, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-301450, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4099714, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4111247, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4144247, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4144968, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4398461, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4404892, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4572117, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4673541, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4695541, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-4725866, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-5010395, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-5013444, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-5039778, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-5288389, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-5684541, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-6017027, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-6042398, http://linkedlifedata.com/resource/pubmed/commentcorrection/308426-947645
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
531-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Longitudinal studies showing alterations in the levels and functional response of T and B lymphocytes in human pregnancy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.