Linked Life Data

3083214

Source:http://linkedlifedata.com/resource/pubmed/id/3083214

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-5-21
pubmed:abstractText
The detection of ANA and the determination of their precise biochemical specificity is an important adjunct to the investigation of patients that have systemic rheumatic disease. Some of these antibodies have clearcut diagnostic and prognostic significance giving the informed clinician important information in the management of diseases with protean manifestations. The performance of the ANA test should be undertaken with a clear understanding of the importance of the substrate being used and the interpretation of certain patterns of staining. For most nuclear antigens (DNA, nRNP, Sm, etc.) cropreserved organ sections are adequate. However, antibodies directed to other antigens (PCNA, centromere, etc.) are best detected on tissue culture cell substrates. The availability of reference sera [99] has become an important advancement in the standarization of these tests. In spite of a large body of literature relating to the biochemistry and clinical significance of these antibodies much more needs to be done to complete our understanding of the role of these antibodies in the pathogenesis of disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0076-681X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
224-60
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Autoantibody testing: procedures and significance in systemic rheumatic diseases.
pubmed:publicationType
Journal Article, Review