Linked Life Data

3082994

Source:http://linkedlifedata.com/resource/pubmed/id/3082994

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-5-7
pubmed:abstractText
In an open study, three different immunoglobulin preparations for intravenous use (IV IgG), namely pH4 and pepsin treated immunoglobulin ('Sandoglobulin'); reduced and alkylated immunoglobulin ('Gamimune') as well as ultrafiltered, pH4 and pepsin treated immunoglobulin manufactured by the Scottish National Blood Transfusion Service ('SNBTS IV IgG'), were compared with intramuscular immunoglobulin (IM IgG) in five patients with primary hypogammaglobulinaemia, by treating each patient consecutively with each immunoglobulin preparation for 3 months. Few adverse reactions were noted with any of the intravenous immunoglobulin preparations and these mainly consisted of mild fever (less than 38 degrees C). Concentrations of serum IgG were higher with all intravenous immunoglobulin preparations compared with IM IgG. Furthermore, all the patients preferred IV to IM IgG therapy. As higher doses of immunoglobulin are associated with a reduction in infections in hypogammaglobulinaemic patients, we conclude that intravenous immunoglobulin therapy should be considered for the prophylaxis of infection in patients with primary hypogammaglobulinaemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0163-4453
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
An evaluation of the safety of three intravenous immunoglobulin preparations in patients with primary hypogammaglobulinaemia.
pubmed:publicationType
Journal Article, Comparative Study