Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1986-5-14
|
| pubmed:abstractText |
The synthesis and antibacterial activity of new ureidopenicillin derivatives having catechol moieties in the 6-acyl side chain are described. These compounds showed remarkably strong activities against Pseudomonas aeruginosa. Especially, 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-methyl-1-ureido]-2- phenylacetamido]penicillanic acid (7a) had the most potent activity in vitro against Gram-negative bacteria, its activity being 30 approximately 60-fold greater than that of piperacillin against most strains of P. aeruginosa.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
230-41
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3082839-Animals,
pubmed-meshheading:3082839-Bacterial Infections,
pubmed-meshheading:3082839-Catechols,
pubmed-meshheading:3082839-Male,
pubmed-meshheading:3082839-Mice,
pubmed-meshheading:3082839-Mice, Inbred Strains,
pubmed-meshheading:3082839-Penicillins,
pubmed-meshheading:3082839-Pseudomonas aeruginosa,
pubmed-meshheading:3082839-Structure-Activity Relationship
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Semisynthetic beta-lactam antibiotics. I. Synthesis and antibacterial activity of new ureidopenicillin derivatives having catechol moieties.
|
| pubmed:publicationType |
Journal Article
|