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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-5-7
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pubmed:abstractText |
The pharmacokinetics of R(-) and S(+)- tocainide were studied in twelve patients requiring intravenous tocainide. In all patients, a progressive increase in the S(+):R(-) ratio was observed during the infusion. Mean +/- s.d. ratios increased from 1.03 +/- 0.05 at 2 min to 1.76 +/- 0.35 at 48.5 h. Data from eight patients were fitted to a two-compartment model and there was a significant difference (Wilcoxon matched-pairs test P less than 0.01) in the clearance estimates for the two enantiomers. The median values were: S(+)-tocainide = 6.25 l h-1 and R(-)-tocainide = 9.31 l h-1. There was no differences in V1 or Vss.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-1269216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-4821443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-513064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-6092093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-6126341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-6411445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-6419760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-6430940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-6439023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-6815740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3082345-7354440
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
149-54
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3082345-Acute Disease,
pubmed-meshheading:3082345-Aged,
pubmed-meshheading:3082345-Anti-Arrhythmia Agents,
pubmed-meshheading:3082345-Arrhythmias, Cardiac,
pubmed-meshheading:3082345-Female,
pubmed-meshheading:3082345-Humans,
pubmed-meshheading:3082345-Kinetics,
pubmed-meshheading:3082345-Lidocaine,
pubmed-meshheading:3082345-Male,
pubmed-meshheading:3082345-Middle Aged,
pubmed-meshheading:3082345-Stereoisomerism,
pubmed-meshheading:3082345-Time Factors,
pubmed-meshheading:3082345-Tocainide
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pubmed:year |
1986
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pubmed:articleTitle |
The pharmacokinetics of R- and S-tocainide in patients with acute ventricular arrhythmias.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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