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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1986-4-1
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pubmed:abstractText |
The genotoxicity and mutagenicity of 11 fungal metabolites structurally related to sterigmatocystin were examined in the hepatocyte primary culture/DNA-repair test and the Salmonella microsome assay. 10 out of the mycotoxins, i.e. dihydrosterigmatocystin, 5-methoxysterigmatocystin, 5-methoxydihydrosterigmatocystin, 5,6-dimethoxysterigmatocystin, 5,6-dimethoxydihydrosterigmatocystin, sterigmatin, O-methylsterigmatocystin and O-acetylsterigmatocystin showed a positive response for DNA repair, suggesting their carcinogenic potency. 5-Methoxysterigmatocystin, 5,6-dimethoxysterigmatocystin demethylsterigmatocystin and O-acetylsterigmatocystin were mutagenic in TA100 of the bacterial mutagenicity assay with liver S9.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-5107
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
217-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3081801-Acetylation,
pubmed-meshheading:3081801-Aflatoxin B1,
pubmed-meshheading:3081801-Aflatoxins,
pubmed-meshheading:3081801-Animals,
pubmed-meshheading:3081801-DNA Repair,
pubmed-meshheading:3081801-Liver,
pubmed-meshheading:3081801-Male,
pubmed-meshheading:3081801-Methylation,
pubmed-meshheading:3081801-Mutagenicity Tests,
pubmed-meshheading:3081801-Rats,
pubmed-meshheading:3081801-Rats, Inbred ACI,
pubmed-meshheading:3081801-Salmonella typhimurium,
pubmed-meshheading:3081801-Sterigmatocystin,
pubmed-meshheading:3081801-Structure-Activity Relationship,
pubmed-meshheading:3081801-Xanthenes
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pubmed:year |
1986
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pubmed:articleTitle |
Genotoxic effects of a variety of sterigmatocystin-related compounds in the hepatocyte/DNA-repair test and the Salmonella microsome assay.
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pubmed:publicationType |
Journal Article,
Comparative Study
|