Linked Life Data

3081413

Source:http://linkedlifedata.com/resource/pubmed/id/3081413

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-3-28
pubmed:abstractText
The effect of the glucose analogs 2-deoxyglucose (2DG), glucosamine (GLA), mannoheptulose (MAN), and gold thioglucose (GTG) on glucose utilization in the mouse ventromedial hypothalamus (VMH) was assessed by using an in vitro incubation system. The amount of 14C-CO2 generated from uniformly labelled 14C-glucose was measured in VMH tissue cubes. MAN and GTG did not alter glucose oxidation at any of the concentrations compared with controls. GLA inhibited glucose utilization but only when the amount of GLA was 3 times that of glucose in the medium. However, this difference was not significant. The 2DG inhibited glucose oxidation significantly (50%; P less than 0.005), but only when 2DG was used in a quantity three-fold greater than glucose. These results imply that the VMH, a reputed central area for controlling feeding behavior, may possess a high affinity for glucose, which is not effectively altered by competitive inhibitors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0018-5043
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14-7
pubmed:dateRevised
2009-2-19
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Glucose analog effects on glucose oxidation in the ventromedial hypothalamus.
pubmed:publicationType
Journal Article, In Vitro