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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1986-2-28
|
| pubmed:abstractText |
Whole-body leucine and plasma glucose kinetics were simultaneously measured in burned rats after 2 d of total parenteral nutrition (TPN) containing sodium DL-3-hydroxybutyrate or sodium acetate to evaluate the ketone bodies as energy substrates during stress. TPN solutions consisted of dextrose and amino acids [200 kcal/(kg . d); 13 g amino acids/(kg . d)] and contained 34.3 mEq/(kg . d) either as sodium DL-3-hydroxybutyrate (n = 8) or sodium acetate (n = 7). Whole-body leucine appearance, incorporation into protein, release from protein breakdown and oxidation rates, as measured after a constant infusion of L-[1-14C]leucine did not significantly differ between the groups. In contrast, D-[6-3H]glucose appearance rates after constant infusion of this tracer were significantly higher in rats given sodium DL-3-hydroxybutyrate [209.3 +/- 3.8 mumol/(kg body weight . min)] than in those given sodium acetate [162.4 +/- 9.7 mumol/(kg body weight . min)] (P less than 0.01). Since leucine kinetics did not differ, the results suggest that sodium DL-3-hydroxybutyrate infusions increase endogenous glucose production [61.0 +/- 4.6 mumol/(100 kg body weight . min)] by enhancing glucose recycling. However, there was no unique protein-sparing effect of ketone bodies identified during injury.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-Hydroxybutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxybutyrates,
http://linkedlifedata.com/resource/pubmed/chemical/Ketone Bodies,
http://linkedlifedata.com/resource/pubmed/chemical/Leucine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-3166
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
116
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
149-56
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3080557-3-Hydroxybutyric Acid,
pubmed-meshheading:3080557-Amino Acids,
pubmed-meshheading:3080557-Animals,
pubmed-meshheading:3080557-Blood Glucose,
pubmed-meshheading:3080557-Burns,
pubmed-meshheading:3080557-Hydroxybutyrates,
pubmed-meshheading:3080557-Infusions, Parenteral,
pubmed-meshheading:3080557-Ketone Bodies,
pubmed-meshheading:3080557-Kinetics,
pubmed-meshheading:3080557-Leucine,
pubmed-meshheading:3080557-Liver,
pubmed-meshheading:3080557-Male,
pubmed-meshheading:3080557-Muscles,
pubmed-meshheading:3080557-Oxygen Consumption,
pubmed-meshheading:3080557-Parenteral Nutrition, Total,
pubmed-meshheading:3080557-Rats,
pubmed-meshheading:3080557-Rats, Inbred Strains,
pubmed-meshheading:3080557-Stress, Physiological
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Effect of DL-3-hydroxybutyrate infusions on leucine and glucose kinetics in burned rats receiving TPN.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|