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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1989-8-14
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pubmed:abstractText |
A multicentre trial with recombinant somatropin was initiated in West Germany in early 1986. Acceptance of patients to the study was determined according to criteria outlined in a detailed study protocol. A total of 62 patients with GH deficiency has now been treated with recombinant somatropin for a minimum of 12 months. Of these, 34 were previously untreated and 28 had previously received pituitary GH. Recombinant somatropin, 12 IU/m2/week, was administered subcutaneously, divided into six doses. Height velocities increased from 3.4 cm/year (pretreatment) to 10.4 cm/year in the previously untreated group, and from 6.0 cm/year during the last year on pituitary GH to 8.3 cm/year for the previously treated patients. Tolerance of recombinant somatropin was good, and no anti-GH antibodies were detected in any of the patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-8843
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
347
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
184-6
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pubmed:dateRevised |
2008-2-20
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pubmed:meshHeading |
pubmed-meshheading:3075837-Adolescent,
pubmed-meshheading:3075837-Body Height,
pubmed-meshheading:3075837-Child,
pubmed-meshheading:3075837-Child, Preschool,
pubmed-meshheading:3075837-Female,
pubmed-meshheading:3075837-Germany, West,
pubmed-meshheading:3075837-Growth Hormone,
pubmed-meshheading:3075837-Humans,
pubmed-meshheading:3075837-Male,
pubmed-meshheading:3075837-Multicenter Studies as Topic,
pubmed-meshheading:3075837-Recombinant Proteins
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pubmed:year |
1988
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pubmed:articleTitle |
Clinical experience with recombinant somatropin: German collaborative study.
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pubmed:affiliation |
Department of Paediatrics, University of Tübingen, West Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Multicenter Study
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