Linked Life Data

3074339

Source:http://linkedlifedata.com/resource/pubmed/id/3074339

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-7-6
pubmed:abstractText
1. Oxytocin is a nonapeptide hormone first isolated in the central nervous system in the supraoptic and paraventricular nuclei of the hypothalamus. Recent studies show that oxytocin is also found in brain regions outside of the hypothalamus and sites of synthesis have been reported in peripheral steroidogenic organs as well. 2. Oxytocin is released from hypothalamic nerve terminals in the posterior pituitary for distribution in the systemic circulation, where it acts to stimulate uterine contraction during parturition and milk let-down during lactation. 3. Although a definitive role for oxytocin in CNS function has not been elucidated, studies in experimental animals suggest involvement in cognition, tolerance and adaptation, and in complex maternal behaviors. Similarly, although oxytocin's function in steroid-producing tissues is not fully established, recent in vitro data has shown that oxytocin can inhibit androgen and estrogen production, and thus may act in a local regulatory fashion. 4. This selective review will highlight some current ideas regarding the functional significance of oxytocin in the central nervous system and review available data concerning the regulation of oxytocin secretion in humans and its potential role in neuropsychiatric illness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0278-5846
pubmed:author
pubmed:issnType
Print
pubmed:volume
12 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S23-51
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Oxytocin: neurobiologic considerations and their implications for affective illness.
pubmed:affiliation
Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, Maryland.
pubmed:publicationType
Journal Article, Review