Linked Life Data

3073454

Source:http://linkedlifedata.com/resource/pubmed/id/3073454

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6B
pubmed:dateCreated
1989-6-19
pubmed:abstractText
In the past few years, one realizes that number of genes whose products are involved in regulating normal cell growth and development are also capable of inducing malignancy. These genes are called oncogenes and include 1 degree the cellular oncogenes (c-onc) or proto-oncogenes and 2 degrees the viral oncogenes (v-onc) which are most likely derived from c-onc and which are the transforming genes of several strains of animal retrovirus. The c-onc are present in the genome of all vertebrate cells and show a remarkable degree of evolutionary conservation, suggesting that they serve essential cellular functions. The analysis of biological properties of both types of oncogenes is of importance to understand the role of proto-oncogenes in normal cell proliferation and/or differentiation and development and to determine how alterations in their structures play a role in malignant transformation. In order to give an overview of the diversity of oncogene activities, several oncogene products involved in growth control, signal transduction, gene expression and development will be described.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0181-1916
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1687-98
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[(Proto)-oncogenes, cellular growth and development].
pubmed:affiliation
Unité de Génétique des Mammifères, Institut Pasteur, Paris.
pubmed:publicationType
Journal Article, English Abstract, Review