Linked Life Data

3072834

Source:http://linkedlifedata.com/resource/pubmed/id/3072834

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-6-8
pubmed:abstractText
The arterial blood pressure (BP), the ratio between gram myocardial mass per 100 g body mass (R), the plasma renin activity (PRA) and the aldosteron content in the blood plasma (PA) were investigated in a model of renal hypertension, 30 days after the operation, in the following groups of male Wistar rats: operated and treated throughout the entire experimental period with captopril Pharmachim in a dose of 30 mg/kg body mass twice daily orally, and two control groups--operated and treated with saline, and non-operated animals of the same age, treated only with saline. BP, R and PA increase significantly in the control group with experimental hypertension. In the group treated with captopril PRA was more than doubled compared with the two control groups, with a considerable decrease in PA compared with the control group with hypertension. The results obtained for the captopril-treated experimental group (with the exception of PRA) are identical and close to the data for the control non-operated animals, i.e. the treatment of the experimental animals with captopril prevents the development of arterial hypertension and of myocardial hypertrophy with the coarctation hypertension model used.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0323-9950
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
20-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Preventive effect of captopril on the development of experimental hypertension in rats.
pubmed:affiliation
Research Chemical-Pharmaceutical Institute, Medical Academy, Sofia.
pubmed:publicationType
Journal Article