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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1989-5-12
|
| pubmed:abstractText |
The discovery of beta-protein, the major component of the amyloid fibrils of the plaques and cerebral vessels and the paired helical filaments of the neurofibrillary tangles, has provided a means to decipher the pathogenesis of Alzheimer's disease. The same lesions in aged Down syndrome individuals have also been shown to be composed of beta-protein. Gene probes localize the gene for beta-protein, as well as that for familial Alzheimer's disease, to chromosome 21. A study of post-translational modifications in the 695 amino acid beta-protein gene precursor with specific reference to abnormal proteolysis may provide insights into the causation of the amyloidotic lesions of Alzheimer's disease.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0753-3322
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
579-84
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
The proteins and genes of Alzheimer's disease.
|
| pubmed:affiliation |
University of California, San Diego, School of Medicine, Department of Pathology, La Jolla 92093.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|