Linked Life Data

3070277

Source:http://linkedlifedata.com/resource/pubmed/id/3070277

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-4-26
pubmed:abstractText
Hepatic microsomal fractions (microsomes) were prepared from female BALB/c mice. The potential of caffeine to modify the ability of microsomes to convert the heterocyclic aromatic amines MeIQ, Trp-P-2 and MeIQx, to bacterial mutagens (indicator: Salmonella typhimurium TA98) was investigated. Caffeine inhibited mutagenicity and did so by inhibiting microsomal metabolism of the three compounds, rather than by altering uptake of the active mutagens and/or interacting with the DNA repair processes in the bacterial cell. Notional Ki values determined for the three heterocyclic amines were similar, suggesting that caffeine inhibits at a stage common to the metabolism of all three compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0267-8357
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
423-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Caffeine inhibits hepatic-microsomal activation of some dietary genotoxins.
pubmed:affiliation
Department of Microbiology, British Industrial Biological Research Association, Carshalton, Surrey, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't