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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1989-4-11
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pubmed:abstractText |
In vivo sensitivity of Plasmodium falciparum to chloroquine was evaluated in 4 of 9 regions of Zaire in 1985 to develop a national strategy for treatment of malaria. Children less than 5 years of age were treated with either a single dose of chloroquine base, 10 mg/kg, or a dose of 25 mg/kg given over 3 d. A modified 7-day World Health Organization in vivo test was used with follow-up 2, 3 and 7 d after the start of treatment. 339 children were studied. In Bwamanda 92% of children were aparasitaemic 7 days after chloroquine, 10 mg/kg, but in Kinshasa only 44% were free of parasites after 25 mg/kg chloroquine. The mean drop in parasite density among those who did not clear parasites by day 7 was greater than 98% of the initial value. Although the parasite density decreased markedly, the failure of most subjects to become aparasitaemic indicated a marked decrease in parasite sensitivity since 1983. Only one child of 51 who were initially febrile remained febrile, although 14 (28%) of these had resistant parasites. The decrease in parasitaemia and temperature, even among children with resistant strains, led the Ministry of Health to recommend 25 mg/kg chloroquine as first line treatment for fever/malaria in their national malaria control plan. The plan includes drug sensitivity surveillance and a referral system for patients who do not respond to chloroquine treatment.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0035-9203
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3068841-Animals,
pubmed-meshheading:3068841-Child, Preschool,
pubmed-meshheading:3068841-Chloroquine,
pubmed-meshheading:3068841-Democratic Republic of the Congo,
pubmed-meshheading:3068841-Drug Resistance,
pubmed-meshheading:3068841-Female,
pubmed-meshheading:3068841-Health Policy,
pubmed-meshheading:3068841-Humans,
pubmed-meshheading:3068841-Malaria,
pubmed-meshheading:3068841-Male,
pubmed-meshheading:3068841-Plasmodium falciparum,
pubmed-meshheading:3068841-Public Health
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pubmed:year |
1988
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pubmed:articleTitle |
Response of children with Plasmodium falciparum to chloroquine and development of a national malaria treatment policy in Zaire.
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pubmed:affiliation |
Childhood Communicable Diseases Program, Ministry of Health, Kinshasa, Zaire.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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