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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-3-21
|
| pubmed:abstractText |
Hind legs of adult rats were exposed to vibrations (81 Hz; amplitude 0.50 mm peak to peak) for 4 h during two consecutive days. The sciatic, tibial and plantar nerves were isolated and processed for immunohistochemical demonstration of IGF-I (insulin-like growth factor I; somatomedin C) immunoreactivity at different time intervals after the vibration exposure. In sham-exposed rats the axons in peripheral nerves showed no or faint IGF-I immunoreactivity while most Schwann cells were negative. Exposure of the hind legs to vibrations induced increased IGF-I immunoreactivity in the Schwann cells, demonstrable at the end of the exposure period and reaching maximal intensity 2-3 days after vibration exposure. Several distended axons similarly showed increased staining. The IGF-I immunoreactivity decreased after 7-10 days to almost the level in the control nerves. The most extensive changes were observed in the plantar nerves. The tibial nerves similarly expressed strongly increased IGF-I immunoreactivity in their Schwann cells. The sciatic nerve showed, however, only slightly to moderately increased staining. Cells in the epineurium of the plantar and, to a limited extent, of the tibial nerves expressed concomitantly increased IGF-I immunoreactivity. We conclude that the transiently increased IGF-I immunoreactivity in peripheral nerves reflects reactive changes caused by vibrations and most prominently expressed by the Schwann cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0001-6772
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
132
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
35-41
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3066119-Animals,
pubmed-meshheading:3066119-Fluorescent Antibody Technique,
pubmed-meshheading:3066119-Insulin-Like Growth Factor I,
pubmed-meshheading:3066119-Male,
pubmed-meshheading:3066119-Microscopy, Fluorescence,
pubmed-meshheading:3066119-Peripheral Nerves,
pubmed-meshheading:3066119-Rats,
pubmed-meshheading:3066119-Rats, Inbred Strains,
pubmed-meshheading:3066119-Sciatic Nerve,
pubmed-meshheading:3066119-Somatomedins,
pubmed-meshheading:3066119-Tibial Nerve,
pubmed-meshheading:3066119-Vibration
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Transient increase in insulin-like growth factor I immunoreactivity in rat peripheral nerves exposed to vibrations.
|
| pubmed:affiliation |
Institute of Neurobiology, University of Göteborg, Sweden.
|
| pubmed:publicationType |
Journal Article
|