Linked Life Data

3062252

Source:http://linkedlifedata.com/resource/pubmed/id/3062252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-2-22
pubmed:abstractText
Studies are reviewed, which establish a novel regulatory role for the T cell lymphokine IL2: Immunoregulation of hematopoiesis. IL2 induces a receptor-specific inhibition of early erythroid progenitors. IL2-induced inhibition of erythropoiesis is mediated by Interferon-gamma protein release preceded by Interferon-gamma mRNA accumulation. Triggering of the antigen receptor complex induces p55 IL2 receptor expression, which is a prerequisite for IL2-induced erythropoietic inhibition. P55 protein expression on the T cell surface is preceded by an increase of p55 mRNA levels. The studies demonstrate that the regulatory role of IL2 extends beyond governance of the immune system itself and can subserve to control red cell production in vitro.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8630
pubmed:author
pubmed:issnType
Print
pubmed:volume
200
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Molecular mechanisms of cellular interaction in immune regulation of hematopoiesis].
pubmed:affiliation
Abteilung für Pädiatrische Hämatologie/Onkologie, Medizinische Einrichtungen der Universität Düsseldorf.
pubmed:publicationType
Journal Article, English Abstract, Review