Linked Life Data

3060819

Source:http://linkedlifedata.com/resource/pubmed/id/3060819

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-1-27
pubmed:abstractText
Aortic stenosis is a well-recognized cause of sudden death, but in our experience, it is uncommon as the sole cause of sudden death. The most common overall cause of AS is the calcified congenitally bicuspid valve. There is an increased incidence of subaortic stenosis in relatives of patients with subaortic stenosis, although Mendelian inheritance has not been reported. Supravalvular AS may be an autosomal dominant with variable penetrance, it may be sporadic, or it may be one of the manifestations of Williams' syndrome. The principal mechanisms of sudden death in AS appear to be due to (1) activation of left ventricular baroreceptors which causes reflex bradycardia and cardiac arrhythmias, or (2) arrhythmias as complications of LVH. Myocardial ischemia has been anatomically proven and may be due to diastolic compression of intramural coronary arteries. Aortic dissection occurs with increased frequency in patients with a bicuspid aortic valve. Heart block can result from calcification of the bundle of His in AS of any cause. Supravalvular AS may be complicated by adherence of an aortic valve cusp to the aorta resulting in coronary ostial stenosis, and coronary narrowing by intimal hyperplasia. AS at any level may lead to IE, which has been responsible for occasional sudden deaths.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0079-0184
pubmed:author
pubmed:issnType
Print
pubmed:volume
23 Pt 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-124
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Sudden death and left ventricular outflow disease.
pubmed:publicationType
Journal Article, Review