Linked Life Data

3059979

Source:http://linkedlifedata.com/resource/pubmed/id/3059979

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1989-1-26
pubmed:abstractText
The concentration of cytosolic free calcium ([Ca2+]i) in living cells is far below than that of plasma and must be extruded against a large electrochemical gradient. Cytosolic Ca2+ is also concentrated by two organelles, the high-affinity, low-capacity endoplasmic reticulum and the low-affinity, high-capacity mitochondria. In liver, different hormones and neurotransmitters mobilize cell glucose by using Ca2+ as an amplifier signal. These agonists promote a fast and large increase in [Ca2+]i as detected by intracellular fluorescent indicators resulting from permeabilization of the endoplasmic reticulum and stimulation of the Ca2+ influx. The hormone action is mediated by rapid hydrolysis of inositol lipids with formation of two messagers inositol [1,4,5]triphosphate and diacylglycerol. Certain bile acids also promote a pronounced release of Ca2+ from the endoplasmic reticulum in liver but independently of the hormone messengers. Mobilization of cell Ca2+ and/or H+ by these cell messengers is involved in a wide variety of other cell functions.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-4266
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
358-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[Calcium and the liver].
pubmed:affiliation
Unité de Recherche INSERM U. 274 Physiologie et Pharmacologie Cellulaire, Université Paris-Sud, Orsay, France.
pubmed:publicationType
Journal Article, English Abstract, Review