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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0004096,
umls-concept:C0205039,
umls-concept:C0242184,
umls-concept:C0547040,
umls-concept:C0600370,
umls-concept:C0681850,
umls-concept:C0871261,
umls-concept:C1550501,
umls-concept:C1704632,
umls-concept:C1706203,
umls-concept:C1706817,
umls-concept:C2349001,
umls-concept:C2349975,
umls-concept:C2697811,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
1989-1-26
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pubmed:abstractText |
We studied the effect of mild isocapnic hypoxia (FIO2 = 15.5%) on lung mechanics, heart rate, circulating plasma catecholamines, and bronchial responsiveness to methacholine in ten asthmatic adults. Hypoxia did not alter lung mechanics (i.e., dynamic pulmonary compliance [CLdyn], pulmonary resistance [RL]) nor did it increase plasma catecholamines, but it significantly increased bronchial responsiveness to aerosolized methacholine, as assessed by the fall in forced expiratory volume in one second (FEV1: 1.2 +/- 0.18 versus 0.9 +/- 0.14 L/s, p less than 0.05), the rise in RL (RL: 19.1 +/- 1.4 versus 8.4 +/- 1 cm H2O/L/s, p less than 0.05), and the steeper slope of the dose-response curve to methacholine. We concluded that the hypoxic characteristic of asthmatic attacks may aggravate airflow obstruction.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-0805
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
789-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3059883-Adult,
pubmed-meshheading:3059883-Anoxia,
pubmed-meshheading:3059883-Asthma,
pubmed-meshheading:3059883-Bronchi,
pubmed-meshheading:3059883-Dose-Response Relationship, Drug,
pubmed-meshheading:3059883-Female,
pubmed-meshheading:3059883-Forced Expiratory Volume,
pubmed-meshheading:3059883-Humans,
pubmed-meshheading:3059883-Lung,
pubmed-meshheading:3059883-Lung Compliance,
pubmed-meshheading:3059883-Male,
pubmed-meshheading:3059883-Methacholine Chloride,
pubmed-meshheading:3059883-Methacholine Compounds
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pubmed:year |
1988
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pubmed:articleTitle |
Mild isocapnic hypoxia enhances the bronchial response to methacholine in asthmatic subjects.
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pubmed:affiliation |
Laboratoire de Physiologie, Hôpital Antoine Béclère, Clamart, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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