Linked Life Data

3059279

Source:http://linkedlifedata.com/resource/pubmed/id/3059279

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1989-1-24
pubmed:abstractText
Enzymatic transformations of androgenic steroids in their target tissues lead to molecules which are androgenically more or less active than testosterone. Among such enzymes, and depending with organs, hydroxylases selectively act upon several androgenic steroids. In testes, the 7 alpha-hydroxylation of biosynthesized testosterone and androstenedione gives molecules implied in the regulation of male hormone production. In prostate, epididymis, sebaceous glands and pituitary, 6 alpha- and 7 alpha-hydroxylations only occur with 5 alpha-reduced and 3 beta-hydroxylated derivatives of 5 alpha-dihydrotestosterone. The cells preferentially dispose of such hydroxylated metabolites, but their formation is decreased by estradiol. The position of hydroxylations in the steroid hormone metabolism of each tissue is shown, and their implication in hormone-dependent pathologic growths are discussed.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0369-8114
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
925-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[Hydroxylation of androgenic steroids in their target organs].
pubmed:affiliation
Laboratoire de Biochimie, Faculté des Sciences, Brest, France.
pubmed:publicationType
Journal Article, English Abstract, Review