Linked Life Data

3057958

Source:http://linkedlifedata.com/resource/pubmed/id/3057958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-1-12
pubmed:abstractText
Airway smooth muscle responses are elicited in a complex manner through a large variety of endogenous mediators. Mediators augment or inhibit bronchomotor tone at a variety of sites through numerous different mechanisms. Interactions occur among mediators and nerves, muscle, and circulating blood elements or respiratory mast cells. Airway smooth muscle tone further is regulated by postsynaptic mediator-mediator interactions. Substances may circulate through the blood from distal sites to reach their target organ, as with epinephrine in its effects on airway smooth muscle, or may be secreted directly onto airway smooth muscle, as with the secretory products of respiratory mast cells. Recent observations have indicated that some mediators elicit airway contraction at least in part by activating efferent parasympathetic nerves and/or platelets. Direct secretion of minute quantities of mediators from adjacent epithelium or from infiltrating leukocytes may be an essential component of airway hyperreactivity. Complex interactions between the complement and kallikrein cascades have been cited as possible mechanisms of airway hyperresponsiveness. Ultimately, bronchomotor tone is mediated postsynaptically by the availability of calcium to the contractile apparatus of the smooth muscle cell. A role for the phosphoinositide system in membrane transduction and for cyclic adenosine monophosphate in regulating calcium distribution for smooth muscle contraction has been implicated. Mediator-mediator interactions distal to the synaptic cleft have been shown to augment both force and duration of airway smooth muscle contraction in a synergistic fashion. The stimuli eliciting mediator and neurotransmitter secretion, their physiologic significance, and the homeostatic infrastructure of these interactions are areas of promising investigation that require further definition.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
137
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1198-216
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Endogenous regulation of bronchomotor tone.
pubmed:affiliation
Section of Pulmonary and Critical Care Medicine, University of Chicago, IL 60637.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review