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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1988-12-30
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pubmed:abstractText |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a member of a family of glycoprotein hormones that stimulate the proliferation and differentiation of hemopoietic cells in vitro and in vivo. We now report that human GM-CSF can also stimulate the proliferation of two osteogenic sarcoma cell lines, a breast carcinoma cell line, a simian virus 40-transformed marrow stromal cell line, and normal marrow fibroblast precursors. These findings suggest a more general regulatory function of GM-CSF on nonhemopoietic cell types than previously anticipated. They also raise the possibility of adverse side effects of GM-CSF therapy in patients whose malignant cells may be directly stimulated by this molecule and suggest a previously unanticipated role of GM-CSF gene activation in the evolution of solid tumors and in the pathogenesis of myelofibrosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-165148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-2430298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-2443508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-2965305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-300377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3018738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3038214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3106013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3281007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3296190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3458209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3486413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3487734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3488126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3488232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3490289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3494201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3496133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3497344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3499986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3500414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3532144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3872885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3877534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3898082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-3923623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-4357757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-6307430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-6390681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-6610831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-6994839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-78051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3057504-883813
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9253-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3057504-Animals,
pubmed-meshheading:3057504-Breast Neoplasms,
pubmed-meshheading:3057504-Cell Division,
pubmed-meshheading:3057504-Cell Line,
pubmed-meshheading:3057504-Colony-Stimulating Factors,
pubmed-meshheading:3057504-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:3057504-Growth Substances,
pubmed-meshheading:3057504-Hematopoietic Stem Cells,
pubmed-meshheading:3057504-Humans,
pubmed-meshheading:3057504-Kinetics,
pubmed-meshheading:3057504-Neuroblastoma,
pubmed-meshheading:3057504-Osteosarcoma,
pubmed-meshheading:3057504-Recombinant Proteins
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pubmed:year |
1988
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pubmed:articleTitle |
Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin.
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pubmed:affiliation |
Department of Advanced Therapeutics, British Columbia Cancer Research Centre, Vancouver, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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