Linked Life Data

3055368

Source:http://linkedlifedata.com/resource/pubmed/id/3055368

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-12-21
pubmed:abstractText
Ninety-three consecutive patients who underwent primary orthotopic hepatic transplantation were treated, after transplantation, with prophylactic immunosuppressive therapy consisting of cyclosporine, prednisone and azathioprine. Weekly percutaneous biopsies were performed to diagnose rejection rapidly. Rejection was treated using a sequential multidrug therapeutic approach based on histologic findings. Mild rejection was initially treated with steroids; moderate to severe rejection was initially treated with steroids; moderate to severe rejection was treated with Minnesota antilymphoblast globulin (mALG) or OKT3 monoclonal antibody (Orthoclone, Ortho Pharmaceutical Corp.), or both. The one year actuarial survival rate for adults was 80 per cent and for children, 70 per cent. The incidence of biopsy-proved rejection was 75 per cent in adults and 80 per cent in children; however, the rejection was relatively easily reversed in both groups using biopsy-guided multimodal therapy. In 21 of 22 patients treated with steroids alone, rejection was reversed. Forty-one patients with moderate to severe rejection required treatment with mALG or OKT3, or both; in 38, rejection was resolved, and in three, chronic rejection required retransplantation. The incidence of bacterial, fungal and viral infections was high after transplantation and was further exacerbated by antirejection therapy requiring mALG Or OKT3, or both. Although the rate of infections was high, most were easily treated with antimicrobial agents. Thus, triple drug immunoprophylaxis followed by biopsy-guided antirejection therapy provided effected treatment of rejection without promoting fatal infections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0039-6087
pubmed:author
pubmed:issnType
Print
pubmed:volume
167
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
474-84
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed-meshheading:3055368-Actuarial Analysis, pubmed-meshheading:3055368-Adolescent, pubmed-meshheading:3055368-Adult, pubmed-meshheading:3055368-Aged, pubmed-meshheading:3055368-Antibodies, Monoclonal, pubmed-meshheading:3055368-Antilymphocyte Serum, pubmed-meshheading:3055368-Azathioprine, pubmed-meshheading:3055368-Biopsy, pubmed-meshheading:3055368-Child, pubmed-meshheading:3055368-Child, Preschool, pubmed-meshheading:3055368-Cyclosporins, pubmed-meshheading:3055368-Drug Evaluation, pubmed-meshheading:3055368-Drug Synergism, pubmed-meshheading:3055368-Follow-Up Studies, pubmed-meshheading:3055368-Graft Rejection, pubmed-meshheading:3055368-Humans, pubmed-meshheading:3055368-Immunosuppressive Agents, pubmed-meshheading:3055368-Infant, pubmed-meshheading:3055368-Liver Transplantation, pubmed-meshheading:3055368-Methylprednisolone, pubmed-meshheading:3055368-Middle Aged, pubmed-meshheading:3055368-Prednisone, pubmed-meshheading:3055368-Reoperation, pubmed-meshheading:3055368-Retrospective Studies, pubmed-meshheading:3055368-Surgical Wound Infection, pubmed-meshheading:3055368-Time Factors
pubmed:year
1988
pubmed:articleTitle
Infection and rejection of primary hepatic transplant in 93 consecutive patients treated with triple immunosuppressive therapy.
pubmed:affiliation
Department of Surgery, University of Minnesota, Minneapolis.
pubmed:publicationType
Journal Article, Comparative Study