| pubmed-article:3055203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3055203 | lifeskim:mentions | umls-concept:C0017398 | lld:lifeskim |
| pubmed-article:3055203 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:3055203 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:3055203 | lifeskim:mentions | umls-concept:C0075290 | lld:lifeskim |
| pubmed-article:3055203 | pubmed:dateCreated | 1988-12-12 | lld:pubmed |
| pubmed-article:3055203 | pubmed:abstractText | Streptococcal M protein is a coiled-coil fibrillar structure extending about 60 nm from the cell wall. From DNA sequencing of the M6 protein gene, it has been determined that the C-terminal end contains a membrane anchor and an adjacent cell wall stabilization domain, both of which are similar to C-terminal regions of surface proteins in other gram-positive organisms. Studies with monoclonal antibodies revealed that the C-terminal half of the protein is conserved among M proteins of different serotypes, whereas the N-terminal half varies. The M protein contains tandem repeats, which, through homologous recombination, are responsible for the observed size variation of the M proteins from different streptococcal strains. M protein size mutants occur in a laboratory-grown culture at a frequency of 1/2,000 colony-forming units. DNA sequence analysis of the M gene in size mutants derived from a single strain suggests that sequence changes which result from homologous recombination may play a role in the antigenic variation of M protein. | lld:pubmed |
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| pubmed-article:3055203 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3055203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3055203 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3055203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3055203 | pubmed:issn | 0162-0886 | lld:pubmed |
| pubmed-article:3055203 | pubmed:author | pubmed-author:ScottJ RJR | lld:pubmed |
| pubmed-article:3055203 | pubmed:author | pubmed-author:FischettiV... | lld:pubmed |
| pubmed-article:3055203 | pubmed:author | pubmed-author:JonesK FKF | lld:pubmed |
| pubmed-article:3055203 | pubmed:author | pubmed-author:HollingsheadS... | lld:pubmed |
| pubmed-article:3055203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3055203 | pubmed:volume | 10 Suppl 2 | lld:pubmed |
| pubmed-article:3055203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3055203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3055203 | pubmed:pagination | S356-9 | lld:pubmed |
| pubmed-article:3055203 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3055203 | pubmed:meshHeading | pubmed-meshheading:3055203-... | lld:pubmed |
| pubmed-article:3055203 | pubmed:meshHeading | pubmed-meshheading:3055203-... | lld:pubmed |
| pubmed-article:3055203 | pubmed:meshHeading | pubmed-meshheading:3055203-... | lld:pubmed |
| pubmed-article:3055203 | pubmed:meshHeading | pubmed-meshheading:3055203-... | lld:pubmed |
| pubmed-article:3055203 | pubmed:meshHeading | pubmed-meshheading:3055203-... | lld:pubmed |
| pubmed-article:3055203 | pubmed:meshHeading | pubmed-meshheading:3055203-... | lld:pubmed |
| pubmed-article:3055203 | pubmed:meshHeading | pubmed-meshheading:3055203-... | lld:pubmed |
| pubmed-article:3055203 | pubmed:meshHeading | pubmed-meshheading:3055203-... | lld:pubmed |
| pubmed-article:3055203 | pubmed:articleTitle | Structure, function, and genetics of streptococcal M protein. | lld:pubmed |
| pubmed-article:3055203 | pubmed:affiliation | Rockefeller University, New York, New York 10021. | lld:pubmed |
| pubmed-article:3055203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3055203 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3055203 | pubmed:publicationType | Review | lld:pubmed |
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