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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1988-12-9
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pubmed:abstractText |
Recombinant human interferon-beta 2 was produced in Escherichia coli by direct expression of cDNA encoding the mature protein sequence. At concentrations that stimulate DNA synthesis and growth in B-cell hybridomas and plasmacytomas, the cytokine was found to exert a strong inhibition on the growth of a number of carcinoma and leukemia/lymphoma cell lines. This antigrowth effect was observed in clonogenic assays and by measurements of cell number and thymidine incorporation in growing cultures. The effect was blocked by antibodies to a synthetic peptide from the N terminus of the molecule. Normal diploid fibroblasts were inhibited at concentrations higher than those needed for breast carcinoma cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-11892816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2416366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2434505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2444978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2445690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2445850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2829354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2866182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2871942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2941150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-2997328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3002607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3023045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3093092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3125790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3305075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3316040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3316421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3491322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3493322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3501121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3538015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3726549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-3883191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-6159547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-6164058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3054878-6376119
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8037-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2.
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pubmed:affiliation |
Department of Virology, Weizmann Institute of Science, Rehovot, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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