Linked Life Data

305433

Source:http://linkedlifedata.com/resource/pubmed/id/305433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-5-8
pubmed:abstractText
The effect of adjuvant on the generation of suppressor cells in the thymus was investigated. C57Bl/6 mice were injected i.p. with complete Freund's adjuvant (CFA), and the capacity of thymocytes and splenic T cells to suppress the in vitro generation of cytolytic T cells was studied. Suppressor thymocytes were detected within two days after CFA inoculation and preceded the appearance of suppressor T cells in the spleen by six days. Characterization of the suppressor thymocyte populations showed that they inhibited primary but not memory T cell responses in vitro. We suggest that the initial step in the regulation of the primary immune response by adjuvant is the generation of suppressor cells in the thymus. Thymic suppressors subsequently migrate to peripheral lymphoid tissue where they inhibit cytotoxic, but no helper, T cell function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-2180
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-97
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Induction of immunoregulatory T cells by adjuvant.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.