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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1979-1-26
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pubmed:abstractText |
The alpha-adrenoceptor blocking agent, tolazoline, and the O-methylated metabolite of adrenaline, metanephrine, produced a concentration-dependent increase of tension in the smooth muscle of the cat isolated nictitating membrane. These effects were considered to be due to the activation of postsynaptic alpha-adrenoceptors. 2 The responses to nerve stimulation of this muscle were neither potentiated nor blocked by tolazoline (0.1 to 10 micrometer) or metanephrine (1 to 10 micrometer). 3 3H-transmitter overflow evoked by electrical stimulation was not modified by tolazoline or metanephrine in concentrations in which these drugs stimulated the postsynaptic alpha-adrenoceptors. 4 Since tolazoline and metanephrine failed to activate the presynaptic alpha-adrenoceptors of the cat nictitating membrane under experimental conditions in which they stimulated the postsynaptic alpha-adrenoceptors, these results further support the view that the presynaptic (alpha2) adrenoceptors differ from the postsynaptic (alpha1) adrenoceptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-1153020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-13435959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-13809081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-14255165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-14389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-14838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-18248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-186273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-197228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-20190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-226338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-4153469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-4155791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-4266252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-4339385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-4363457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-4427289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-4617579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-5224050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-5451365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-5498506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-5684282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-6048012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/30506-6285
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-64
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:30506-Animals,
pubmed-meshheading:30506-Cats,
pubmed-meshheading:30506-Electric Stimulation,
pubmed-meshheading:30506-Epinephrine,
pubmed-meshheading:30506-Female,
pubmed-meshheading:30506-Male,
pubmed-meshheading:30506-Metanephrine,
pubmed-meshheading:30506-Muscle, Smooth,
pubmed-meshheading:30506-Muscle Contraction,
pubmed-meshheading:30506-Neurotransmitter Agents,
pubmed-meshheading:30506-Nictitating Membrane,
pubmed-meshheading:30506-Receptors, Adrenergic,
pubmed-meshheading:30506-Receptors, Adrenergic, alpha,
pubmed-meshheading:30506-Tolazoline
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pubmed:year |
1978
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pubmed:articleTitle |
Differences between presynaptic and postsynaptic alpha-adrenoceptors in the isolated nictitating membrane of the cat: effects of metanephrine and tolazoline.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
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