Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1988-11-3
|
| pubmed:abstractText |
The transplantation of bone marrow cells from BALB/c (but not C57BL/6 and C3H/HeN) mice was observed to lead to the development of thymic lymphomas (leukemias) in AKR/J mice. Two leukemic cell lines, CAK1.3 and CAK4.4, were established from the primary culture of two thymic lymphoma, and surface phenotypes of these cell lines found to be H-2d and Thy-1.2+, indicating that these lymphoma cells are derived from BALB/c donor bone marrow cells. Further analyses of surface markers revealed that CAK1.3 is L3T4+ Lyt2+ IL2R-, whereas CAK4.4 is L3T4- Lyt2- IL2R+. Both CAK1.3 and CAK4.4 were transplantable into BALB/c but not AKR/J mice, further indicating that these cells are of BALB/c bone marrow donor origin. The cells were found to produce XC+-ecotropic viruses, but xenotropic and mink cell focus-forming viruses were undetectable. Inasmuch as thymic lymphomas are derived from bone marrow cells of leukemia-resistant BALB/c strain of mice under the allogeneic environment of leukemia-prone AKR/J mice, this animal model may serve as a useful tool not only for the analysis of leukemic relapse after bone marrow transplantation but also for elucidation of the mechanism of leukemogenesis.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
141
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
2181-6
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3049801-Animals,
pubmed-meshheading:3049801-Antigens, Surface,
pubmed-meshheading:3049801-Bone Marrow Transplantation,
pubmed-meshheading:3049801-Cell Line,
pubmed-meshheading:3049801-Female,
pubmed-meshheading:3049801-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:3049801-Mice,
pubmed-meshheading:3049801-Mice, Inbred AKR,
pubmed-meshheading:3049801-Mice, Inbred BALB C,
pubmed-meshheading:3049801-Mice, Inbred C3H,
pubmed-meshheading:3049801-Mice, Inbred C57BL,
pubmed-meshheading:3049801-Phenotype,
pubmed-meshheading:3049801-Radiation Chimera,
pubmed-meshheading:3049801-Retroviridae,
pubmed-meshheading:3049801-Species Specificity,
pubmed-meshheading:3049801-T-Lymphocytes,
pubmed-meshheading:3049801-Thymus Neoplasms,
pubmed-meshheading:3049801-Tissue Donors
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice.
|
| pubmed:affiliation |
Department of Pathology, Kansai Medical University, Osaka, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|