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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-11-15
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pubmed:abstractText |
The hematopoietic stimulatory activities of human recombinant IL-3 and granulocyte-macrophage colony stimulating factor (GM-CSF) were directly compared using highly enriched human bone marrow progenitor target cells. IL-3 supported a larger number of erythroid and megakaryocytic progenitor cells than did GM-CSF, while GM-CSF supported more myeloid progenitors. IL-3 directly stimulated the division and migration of primitive erythroid burst forming units, while GM-CSF merely sustained their net survival in culture without promoting division and expansion. IL-3 promoted the formation of larger numbers of multipotential granulocyte-erythroid-macrophage-megakaryocyte colony forming unit--derived colonies than did GM-CSF. These data indicate that human IL-3 and GM-CSF have overlapping but distinct hematopoietic activities, and suggest a potential role for the clinical application of combined IL-3/GM-CSF therapy.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-313401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3464448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3489530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3493529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3495551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3818641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3838366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3871951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3875629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3876355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3877534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3877981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-3923623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-4044652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-6501566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-6690455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-6733267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-6802859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-6965346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-6987658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3049674-7421991
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1282-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3049674-Adult,
pubmed-meshheading:3049674-Bone Marrow Cells,
pubmed-meshheading:3049674-Cell Division,
pubmed-meshheading:3049674-Cell Movement,
pubmed-meshheading:3049674-Colony-Forming Units Assay,
pubmed-meshheading:3049674-Colony-Stimulating Factors,
pubmed-meshheading:3049674-Erythroblasts,
pubmed-meshheading:3049674-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:3049674-Growth Substances,
pubmed-meshheading:3049674-Hematopoiesis,
pubmed-meshheading:3049674-Hematopoietic Stem Cells,
pubmed-meshheading:3049674-Humans,
pubmed-meshheading:3049674-Interleukin-3,
pubmed-meshheading:3049674-Megakaryocytes,
pubmed-meshheading:3049674-Recombinant Proteins
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pubmed:year |
1988
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pubmed:articleTitle |
Human recombinant granulocyte-macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities.
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pubmed:affiliation |
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109.
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pubmed:publicationType |
Journal Article,
Comparative Study
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