Linked Life Data

3047126

Source:http://linkedlifedata.com/resource/pubmed/id/3047126

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
26
pubmed:dateCreated
1988-10-19
pubmed:abstractText
The COUP (chicken ovalbumin upstream promoter) transcription factor binds to the upstream promoters of both the chicken ovalbumin and the rat insulin II genes, even though the two binding sites have no obvious sequence similarity (Hwung, Y.-P., Crowe, D. T., Wang, L.-H., Tsai, S. Y., and Tsai, M.-J. (1988) Mol. Cell. Biol. 8, 2070-2077). Comparison of the contact points and important nucleotides in the two binding sites suggests that the COUP transcription factor binds to them in different ways. The purine contacts in the two promoters are limited to one face of the DNA helix; however, studies on phosphate contacts suggest that the COUP transcription factor wraps around the ovalbumin promoter, while it binds to only one face of the DNA helix in the insulin promoter. In addition, the binding factor makes a more extended contact on the insulin promoter as compared to the ovalbumin promoter. The potential significance of this novel finding is discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
263
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13470-4
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Differential binding of the chicken ovalbumin upstream promoter (COUP) transcription factor to two different promoters.
pubmed:affiliation
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.