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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1988-10-27
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pubmed:abstractText |
Sera from 11 patients with fulminant hepatitis B were tested for antibodies to translation products of the pre-S1 and pre-S2 regions of hepatitis B virus of IgM, IgA and IgG classes, as well as of IgA1, IgA2 and SIgA, with solid-phase enzyme immunoassays using native viral polypeptides. Antibodies to pre-S1 region product of IgM and/or IgA class were detected invariably in six patients who still had detectable hepatitis B surface antigen in serum at the time of clinical presentation. The remaining five patients who had lost HBsAg at presentation had antibodies to pre-S region products of various immunoglobulin classes in higher titers. The five patients with fulminant hepatitis without HBsAg had higher levels of IgA antibodies to pre-S region products than the seven patients with nonfulminant acute hepatitis B who had lost HBsAg: IgA antibody to pre-S1 region product (75.6 +/- 63.8 vs. 2.9 +/- 3.2, p less than 0.01) and IgA antibody to pre-S2 region product (28.9 +/- 25.3 vs. 4.2 +/- 6.9, p less than 0.01). IgA antibodies to pre-S1 and pre-S2 region products were invariably polymeric in fulminant hepatitis B. These findings are compatible with the hypothesis that a heightened humoral antibody response to pre-S1 and pre-S2 region products occurs early during the course of fulminant hepatitis B, participating in severe hepatic injury and early clearance of virus characteristic of this disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Surface Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A, Secretory,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/presurface protein 1, hepatitis B...,
http://linkedlifedata.com/resource/pubmed/chemical/presurface protein 2, hepatitis B...
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pubmed:status |
MEDLINE
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pubmed:issn |
0270-9139
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1089-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3047036-Acute Disease,
pubmed-meshheading:3047036-Genes, Viral,
pubmed-meshheading:3047036-Hepatitis B,
pubmed-meshheading:3047036-Hepatitis B Antibodies,
pubmed-meshheading:3047036-Hepatitis B Surface Antigens,
pubmed-meshheading:3047036-Hepatitis B virus,
pubmed-meshheading:3047036-Humans,
pubmed-meshheading:3047036-Immunoenzyme Techniques,
pubmed-meshheading:3047036-Immunoglobulin A,
pubmed-meshheading:3047036-Immunoglobulin A, Secretory,
pubmed-meshheading:3047036-Immunoglobulin G,
pubmed-meshheading:3047036-Immunoglobulin M,
pubmed-meshheading:3047036-Protein Biosynthesis,
pubmed-meshheading:3047036-Protein Precursors,
pubmed-meshheading:3047036-Viral Envelope Proteins
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pubmed:articleTitle |
Antibodies to translation products of the pre-S1 and pre-S2 regions of the envelope gene of hepatitis B virus in fulminant hepatitis B.
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pubmed:affiliation |
Hepatitis Division, Tokyo Metropolitan Institute of Medical Sciences, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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