Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1988-10-27
|
| pubmed:abstractText |
The trace element vanadium (V) exerts insulin-like effects in vitro. The present study examined its effects on glucose homeostasis in rats made diabetic by streptozotocin. Na3VO4 (0.2 or 0.5 mg/ml) was administered ad libitum in drinking water. Fed plasma glucose levels (approximately 26 mmol/liter) fell by 30% and 56% after 5 days of treatment with the low (VO.2) and high (VO.5) concentrations of vanadate, respectively. This decrease was not due to a rise in peripheral insulin levels and persisted for more than 2 months. Daily glucosuria was decreased by 60% and 85% in VO.2 and VO.5 rats, respectively. Tolerance of the rats to oral or iv glucose was also considerably improved by vanadate; integrated glucose responses were about 55% and 75% lower in VO.2 and VO.5 rats than in controls, and the differences were not due to restoration of insulin release. Compared to nondiabetic rats, pancreatic insulin reserves amounted to 1% in untreated rats, 3% in VO.2 rats, and 6% in VO.5 rats after 9 weeks of treatment. Liver, but not muscle, glycogen was increased by vanadate. Despite improvement of their diabetic state, vanadate-treated rats did not gain more weight than untreated rats. Their food intake (corrected for urinary glucose losses) was decreased by about 25%. No signs of altered kidney or liver function were observed in rats receiving vanadate. In conclusion, vanadate markedly improves glucose homeostasis in streptozotocin-diabetic rats by an insulin-like mechanism, but does not reproduce the anabolic effects of the hormone.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Liver Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Vanadates
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0013-7227
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
123
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2048-53
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3046930-Animals,
pubmed-meshheading:3046930-Blood Glucose,
pubmed-meshheading:3046930-Diabetes Mellitus, Experimental,
pubmed-meshheading:3046930-Glucose,
pubmed-meshheading:3046930-Glucose Tolerance Test,
pubmed-meshheading:3046930-Glycogen,
pubmed-meshheading:3046930-Glycosuria,
pubmed-meshheading:3046930-Homeostasis,
pubmed-meshheading:3046930-Insulin,
pubmed-meshheading:3046930-Islets of Langerhans,
pubmed-meshheading:3046930-Liver,
pubmed-meshheading:3046930-Liver Glycogen,
pubmed-meshheading:3046930-Male,
pubmed-meshheading:3046930-Muscles,
pubmed-meshheading:3046930-Rats,
pubmed-meshheading:3046930-Rats, Inbred Strains,
pubmed-meshheading:3046930-Reference Values,
pubmed-meshheading:3046930-Vanadates
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Long term improvement of glucose homeostasis by vanadate treatment in diabetic rats.
|
| pubmed:affiliation |
Unité de Diabétologie et Nutrition, University of Louvain, Faculty of Medicine, Brussels, Belgium.
|
| pubmed:publicationType |
Journal Article
|