3043414

Source:http://linkedlifedata.com/resource/pubmed/id/3043414

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0008509, umls-concept:C0008976, umls-concept:C0023981, umls-concept:C0032979, umls-concept:C0314603, umls-concept:C1274040, umls-concept:C2587213
pubmed:issue	5
pubmed:dateCreated	1988-9-15
pubmed:abstractText	This controlled prospective study assesses the relative risks of first trimester chorionic villus sampling (CVS) versus mid-trimester gentic amniocentesis (GA). CVS subjects and amniocentesis controls were comparable with regard to several confounding variables which might influence the risk of pregnancy loss including maternal age, smoking, alcohol consumption, gestational age at study entry, and history of vaginal bleeding or poor prior reproductive outcome. The most common indication for prenatal diagnosis was advanced maternal age (n = 511). In this subgroup, spontaneous abortion (less than 24 weeks) occurred in 2.9 per cent of CVS subjects versus 4.3 per cent of amniocentesis controls. The sum of spontaneous and therapeutic abortions (less than 24 weeks) was identical (5.3 per cent) in both groups. Therefore, intervention in the CVS group (i.e., therapeutic abortion for cytogenetic abnormalities) did not influence the observed risk of pregnancy loss. Overall perinatal mortality rates were also similar in both groups. No significant differences were identified for a number of pregnancy outcome parameters including 5 min Apgar score, birth weight, body length, head circumference, gestational age at delivery, preterm delivery, fetal growth retardation, congenital malformations, and neonatal complications. Preliminary results of this controlled prospective study suggest that chorionic villus sampling carries a low and acceptable risk.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8106540
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0197-3851
pubmed:author	pubmed-author:BeaverH AHA, pubmed-author:CheungS WSW, pubmed-author:CraneJ PJP
pubmed:issnType	Print
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	355-66
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:3043414-Abortion, Spontaneous, pubmed-meshheading:3043414-Adult, pubmed-meshheading:3043414-Amniocentesis, pubmed-meshheading:3043414-Chorionic Villi, pubmed-meshheading:3043414-Chromosome Aberrations, pubmed-meshheading:3043414-Chromosome Disorders, pubmed-meshheading:3043414-Clinical Trials as Topic, pubmed-meshheading:3043414-Female, pubmed-meshheading:3043414-Fetal Diseases, pubmed-meshheading:3043414-Humans, pubmed-meshheading:3043414-Maternal Age, pubmed-meshheading:3043414-Pregnancy, pubmed-meshheading:3043414-Pregnancy, High-Risk, pubmed-meshheading:3043414-Pregnancy Trimester, First, pubmed-meshheading:3043414-Pregnancy Trimester, Second, pubmed-meshheading:3043414-Prenatal Diagnosis, pubmed-meshheading:3043414-Prospective Studies, pubmed-meshheading:3043414-Risk Factors
pubmed:year	1988
pubmed:articleTitle	First trimester chorionic villus sampling versus mid-trimester genetic amniocentesis--preliminary results of a controlled prospective trial.
pubmed:affiliation	Department of Obstetrics and Gynecology, Washington University School of Medicine, Jewish Hospital, St Louis, MO 63110.
pubmed:publicationType	Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial