Linked Life Data

3043179

Source:http://linkedlifedata.com/resource/pubmed/id/3043179

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-9-16
pubmed:abstractText
Transin is a transformation-associated gene which is expressed constitutively in rat fibroblasts transformed by a variety of oncogenes and in malignant mouse skin carcinomas but not benign papillomas or normal skin. It has been demonstrated that, in nontransformed Rat-1 cells, transin RNA expression is modulated positively by epidermal growth factor (EGF) and negatively by transforming growth factor beta (TGF-beta); other peptide growth factors were found to have no effect on transin expression. Results presented here indicate that both protein synthesis and continuous occupancy of the EGF receptor by EGF were required for sustained induction of transin RNA. Treatment with TGF-beta inhibited the ability of EGF to induce transin, whether assayed at the transcriptional level by nuclear run-on analysis or at the level of transin RNA accumulation by Northern (RNA) blot analysis of cellular RNA. TGF-beta both blocked initial induction of transin transcription by EGF and halted established production of transin transcripts during prolonged treatment. These results suggest that TGF-beta acts at the transcriptional level to antagonize EGF-mediated induction of transin gene expression.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-178887, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-2431284, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-3007488, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-3009463, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-3030290, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-3033652, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-3540938, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-3875482, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-4636326, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-6270169, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-6593703, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-6602130, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-6983841, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-6984857, http://linkedlifedata.com/resource/pubmed/commentcorrection/3043179-94421
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2479-83
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Transcriptional modulation of transin gene expression by epidermal growth factor and transforming growth factor beta.
pubmed:affiliation
Department of Cell Biology and Anatomy, Oregon Health Sciences University, Portland 97201.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.