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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1988-9-21
|
| pubmed:abstractText |
Antisera were obtained upon immunization of rabbits with the extracts obtained from metastatic tissues of primary ovarian carcinoma into the omentum. Eight antigens were found, which were termed "ovarian-metastatic antigens" (OMA). OMA 1-7 showed cross-reactions with the antigens of one of the normal organs of the adult man: kidneys, spleen, brain. OMA-8 was not identified in the internal organ tissues of the adults and fetuses. Using immunodiffusion method, OMA-8 was revealed in the tissues of metastases of primary ovarian cancer into the omentum in 55% of cases (3-180 mg/l), in 50% of cases it was detected in primary ovarian carcinomas (3-50 mg/l) and in mature placenta (38-40 weeks) (6-12 mg/l). OMA-8 was detected in the chorion (8-20 weeks) and in the amniotic fluid at all periods at the maximum sensitivity of immunodiffusion method (1-2 mg/l). OMA-8 is a beta 2-globulin of protein nature with NW 35 kD, containing alpha- and beta-subunits with MW 18 and 19.5 kD. No carbohydrates, lipids and ferrum were determined in OMA-8. Its physico-chemical and antigenic properties differ from those of the described carcinoembryonic and placental proteins.
|
| pubmed:language |
rus
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0365-9615
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
106
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
81-3
|
| pubmed:dateRevised |
2008-10-8
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
[Immunochemical identification of beta2-globulin in metastases of ovarian tumors].
|
| pubmed:publicationType |
Journal Article,
In Vitro,
English Abstract
|