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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1988-8-30
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pubmed:abstractText |
The effect of Schwann cell-conditioned medium (SCM) on the development in vitro of spinal cord neurons was studied. Spinal cord neurons from 18-day-old rat embryos were cultured in serum-free conditioned medium obtained from confluent rat Schwann cells. In cultures fed SCM, the cells developed typical neuronal morphology and were identified by indirect immunofluorescence using a monoclonal antibody to neurofilament protein. SCM stimulated neurite outgrowth and supported survival of spinal cord neurons. Preliminary characterization suggests that the neurotrophic factor in SCM appears to be a protein with a molecular weight greater than 8000 daltons.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0148-639X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
11
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
324-30
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3041275-Animals,
pubmed-meshheading:3041275-Axons,
pubmed-meshheading:3041275-Cell Survival,
pubmed-meshheading:3041275-Cells, Cultured,
pubmed-meshheading:3041275-Culture Media,
pubmed-meshheading:3041275-Fluorescent Antibody Technique,
pubmed-meshheading:3041275-Neurons,
pubmed-meshheading:3041275-Schwann Cells,
pubmed-meshheading:3041275-Spinal Cord
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pubmed:year |
1988
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pubmed:articleTitle |
Schwann cell-conditioned medium supports neurite outgrowth and survival of spinal cord neurons in culture.
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pubmed:affiliation |
Department of Neurology, University of Iowa College of Medicine, Iowa.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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