Linked Life Data

3040174

Source:http://linkedlifedata.com/resource/pubmed/id/3040174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-10-15
pubmed:abstractText
The effects of two CCK antagonists, benzotript and proglumide, and of sulfated and non-sulfated cholecystokinin octapeptide (CCK-8-S and CCK-8-NS), were studied in the CA1 region of the rat hippocampal slice. Both benzotript and proglumide shifted presynaptic volley (prevolley) vs population spike input/output (I/O) curves for Schaffer collateral-commissural synaptic transmission to the right. This result indicates that the antagonists had a net depressant effect on synaptic transmission. CCK-8-S shifted prevolley vs population spike I/O curves to the left, indicating a net excitatory effect. Analysis of component I/O curves indicated that CCK-8-S and the CCK antagonists were acting postsynaptically by changing CA1 pyramidal cell threshold. CCK-8-NS had no significant effect on overall or component I/O functions. These findings suggest that endogenous CCK is released, directly or indirectly, upon stimulation of the Schaffer collateral-commissural fibers and increases the excitability of CA1 pyramidal cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
415
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-203
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The effects of cholecystokinin and cholecystokinin antagonists on synaptic function in the CA1 region of the rat hippocampal slice.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.