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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
1987-9-22
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pubmed:abstractText |
M protein, a major surface protein and virulence factor for the group A streptococcus, exhibits extraordinary size variation in strains of the same serotype (Fischetti et al. 1985). RNA sequence analysis of spontaneous M protein size variants shows that deletion mutations arise in a single strain by homologous recombination events between intragenic tandem repeats. Similar deletion and duplication events also occur in serial streptococcal isolates from a single patient and among related strains in a recent outbreak. We discuss how homologous recombination events can lead to the generation of antigenic variation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0026-8925
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
207
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
196-203
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3039291-Antigens, Bacterial,
pubmed-meshheading:3039291-Bacterial Outer Membrane Proteins,
pubmed-meshheading:3039291-Bacterial Proteins,
pubmed-meshheading:3039291-Biological Evolution,
pubmed-meshheading:3039291-Carrier Proteins,
pubmed-meshheading:3039291-DNA Restriction Enzymes,
pubmed-meshheading:3039291-Genes,
pubmed-meshheading:3039291-Genes, Bacterial,
pubmed-meshheading:3039291-Genetic Variation,
pubmed-meshheading:3039291-Mutation,
pubmed-meshheading:3039291-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:3039291-Streptococcus pyogenes
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pubmed:year |
1987
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pubmed:articleTitle |
Size variation in group A streptococcal M protein is generated by homologous recombination between intragenic repeats.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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