Linked Life Data

3039020

Source:http://linkedlifedata.com/resource/pubmed/id/3039020

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-9-1
pubmed:abstractText
The role of Papillomavirus (PV) in the development of external genital neoplasias has recently been documented. Fifty cases of condyloma acuminata, dystrophy, Bowenoid papulosis, carcinoma in situ and invasive carcinoma of the vulva were examined for the presence of PV structural antigens with an immunoperoxidase method on formalin-fixed, paraffin-embedded tissue. Using the avidin-biotin-peroxidase complex (ABC) technique on vulvar tissue obtained from biopsy and vulvectomy specimens, PV structural antigens were identified in association with condyloma acuminata in 5 of 6 cases (83.3%), with hyperplastic dystrophy in 1 of 11 cases (9.1%), with atypia in 9 of 14 cases (64.3%), with Bowenoid papulosis in 2 of 2 cases (100%), with carcinoma in situ in 4 of 7 cases (57.1%) and with invasive carcinoma in three of 3 cases (100%), but in none of the examples of 7 lichen sclerosus cases. A PV-inducing morphologic change in koilocytosis was present in 30 instances of all the vulvar lesions. The results of this study, therefore, provide immunohistochemical evidence demonstrating the close relationship of papillomavirus to vulvar disease ranging from condyloma acuminata and moderate atypia to carcinoma in situ and invasive carcinoma.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0300-9165
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
959-64
pubmed:dateRevised
2011-7-29
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Papillomavirus infection of the vulva].
pubmed:publicationType
Journal Article, English Abstract