Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-8-31
pubmed:databankReference
pubmed:abstractText
A cDNA encoding the precursor of the bovine mitochondrial phosphate carrier protein has been cloned from a bovine cDNA library using a mixture of 128 different 17-mer oligonucleotides as hybridisation probe. The protein has an N-terminal extension of 49 amino acids not present in the mature protein. This extension has a net positive charge and is presumed to direct the import of the protein from the cytoplasm to the mitochondrion. Comparison of the protein sequence of the mature phosphate carrier with itself, with ADP/ATP translocase and with the uncoupling protein from brown fat mitochondria shows that all three proteins contain a 3-fold repeated sequence approximately 100 amino acids in length, and that the repeats in the three proteins are related to each other. This implies that the three proteins have related three-dimensional structures and mechanisms and that they share a common evolutionary origin. The distribution of hydrophobic residues in the phosphate carrier protein suggests that each repeated 100 amino acid element is composed of two membrane-spanning alpha-helices linked by an extensive hydrophilic domain. This model is similar to that first proposed for the ADP/ATP translocase and later for the brown fat mitochondria uncoupling protein.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-2868890, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-2870059, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-287063, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-3000775, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-3023860, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-3753702, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-3800890, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-3838468, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-3840803, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-386835, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-38739, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-4066697, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-4504350, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-4613381, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6087898, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6092058, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6093095, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6154866, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6288471, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6294090, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6295879, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6295880, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6297790, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6300857, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6325169, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6329691, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6364040, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6372096, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6575390, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-6746642, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-7076130, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-7099970, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-7108955, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-7133997, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-7232224, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-7316989, http://linkedlifedata.com/resource/pubmed/commentcorrection/3038521-822353
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/DNA Restriction Enzymes, http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial ADP, ATP Translocases, http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nucleotidyltransferases, http://linkedlifedata.com/resource/pubmed/chemical/Phosphate-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein, http://linkedlifedata.com/resource/pubmed/chemical/uncoupler-binding protein, Bos...
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1367-73
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:3038521-Adipose Tissue, Brown, pubmed-meshheading:3038521-Amino Acid Sequence, pubmed-meshheading:3038521-Animals, pubmed-meshheading:3038521-Base Sequence, pubmed-meshheading:3038521-Carrier Proteins, pubmed-meshheading:3038521-Cattle, pubmed-meshheading:3038521-Cloning, Molecular, pubmed-meshheading:3038521-DNA, pubmed-meshheading:3038521-DNA Restriction Enzymes, pubmed-meshheading:3038521-Genes, pubmed-meshheading:3038521-Ion Channels, pubmed-meshheading:3038521-Membrane Proteins, pubmed-meshheading:3038521-Mitochondria, pubmed-meshheading:3038521-Mitochondria, Heart, pubmed-meshheading:3038521-Mitochondrial ADP, ATP Translocases, pubmed-meshheading:3038521-Mitochondrial Proteins, pubmed-meshheading:3038521-Nucleotidyltransferases, pubmed-meshheading:3038521-Phosphate-Binding Proteins
pubmed:year
1987
pubmed:articleTitle
Sequence of the bovine mitochondrial phosphate carrier protein: structural relationship to ADP/ATP translocase and the brown fat mitochondria uncoupling protein.
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