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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-7-24
|
| pubmed:abstractText |
The effects of spontaneous respiration and mechanical ventilation were examined by investigating the interaction between elevated intracranial pressure and alcohol intoxication. Ethanol (200 ml 48%) was infused in 11 young pigs with elevated cerebral pressure during mechanical ventilation (group 1), 7 young pigs with elevated cerebral pressure during spontaneous respiration (group 2), and 4 young pigs without elevated cerebral pressure during spontaneous respiration (group 3). While the behavior of intracranial pressure during mechanical ventilation in the animals from group 1 was inhomogeneous with a tendency to rise (29-34 mmHg), cerebral pressure (28-55 mmHg) increased drastically in the animals from group 2. This increase was associated with a sharp rise of Pa,CO2 (37.6-73.3 mmHg) and a decrease of Pa,O2 (74 mmHg to 13 mmHg). None of the animals in group 2 survived. Pa,CO2 also rose in alcoholized animals without elevated cerebral pressure (group 3) (41.9-63.9 mmHg); intracranial pressure, however, remained within the normal range. All animals in group 3 survived. Our findings indicate that elevated intracranial pressure and alcohol intoxication have a cumulative or potentiating effect on depression of the respiratory center. Respiratory depression can be prevented by mechanical ventilation and, therefore, a further rise of intracranial pressure generally avoided.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0300-9572
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
125-33
|
| pubmed:dateRevised |
2009-8-25
|
| pubmed:meshHeading |
pubmed-meshheading:3037660-Alcoholic Intoxication,
pubmed-meshheading:3037660-Animals,
pubmed-meshheading:3037660-Blood Gas Analysis,
pubmed-meshheading:3037660-Disease Models, Animal,
pubmed-meshheading:3037660-Electroencephalography,
pubmed-meshheading:3037660-Female,
pubmed-meshheading:3037660-Intracranial Pressure,
pubmed-meshheading:3037660-Male,
pubmed-meshheading:3037660-Respiration, Artificial,
pubmed-meshheading:3037660-Respiratory Insufficiency,
pubmed-meshheading:3037660-Swine
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
The respiratory aspect of the treatment of brain injury associated with acute alcohol intoxication--results of an animal experiment.
|
| pubmed:publicationType |
Journal Article
|