|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6127
|
|
pubmed:dateCreated |
1987-8-14
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0028-0836
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
328
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
221-7
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:3037384-Animals,
pubmed-meshheading:3037384-Cattle,
pubmed-meshheading:3037384-Cloning, Molecular,
pubmed-meshheading:3037384-DNA,
pubmed-meshheading:3037384-Gene Expression Regulation,
pubmed-meshheading:3037384-Membrane Proteins,
pubmed-meshheading:3037384-Multigene Family,
pubmed-meshheading:3037384-Oocytes,
pubmed-meshheading:3037384-Protein Conformation,
pubmed-meshheading:3037384-Receptors, GABA-A,
pubmed-meshheading:3037384-Receptors, Nicotinic,
pubmed-meshheading:3037384-gamma-Aminobutyric Acid
|
|
pubmed:articleTitle |
Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
