|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1987-8-19
|
|
pubmed:abstractText |
Human erythrocyte membranes catalyse the NAD(P)H-dependent generation of the semiquinone of an adriamycin-type antibiotic carminomycin under anaerobic conditions. The maximal yield of the antibiotic radical is about 4-fold higher in the presence of NADPH than of NADH. The possible significance of the antibiotic reduction to the semiquinone by a human erythrocyte membrane redox chain for the clinical usage of these antibiotics is discussed.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
13
|
|
pubmed:volume |
219
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
212-4
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:3036597-Carubicin,
pubmed-meshheading:3036597-Daunorubicin,
pubmed-meshheading:3036597-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:3036597-Electrons,
pubmed-meshheading:3036597-Erythrocyte Membrane,
pubmed-meshheading:3036597-Free Radicals,
pubmed-meshheading:3036597-Humans,
pubmed-meshheading:3036597-Kinetics,
pubmed-meshheading:3036597-NAD,
pubmed-meshheading:3036597-NADP,
pubmed-meshheading:3036597-Oxidation-Reduction
|
|
pubmed:year |
1987
|
|
pubmed:articleTitle |
One-electron reduction of an anthracycline antibiotic carminomycin by a human erythrocyte redox chain.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
