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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1987-7-31
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pubmed:abstractText |
Lymphoid cell lines were isolated that were inducible for the expression of surface immunoglobulin by shift from 35.5 to 39.5 degrees C after infection of mouse bone marrow cells with a mutagen-treated Abelson murine leukemia virus. Virus produced by one of the cell lines (ts49) transmitted the temperature-sensitive phenotype to new lymphoid transformants as well as to NIH/3T3 cells. In addition, the tyrosine autophosphorylating activity of the p120gag-abl protein synthesized in ts49-transformed cells was found to be temperature-sensitive. Shift experiments using ts49-transformed lymphoid cells showed that at 39.5 degrees C they synthesize increased amounts of mu and kappa chain RNA and protein, and that they can be further induced to secrete IgM when treated with lipopolysaccharide.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-103631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-10872333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-111144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-117905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-163444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-178822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-206644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-206646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-211440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-2983108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-308074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-3082520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-3095662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-3930970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-4318922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6095102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6096011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6185617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6244493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6254050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6257926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6258948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6275106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6287020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6291785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6299581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6324199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6408480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6608556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6610061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6611268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6690619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6791945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6810096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-6975314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3036494-97089
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
951-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3036494-Abelson murine leukemia virus,
pubmed-meshheading:3036494-Animals,
pubmed-meshheading:3036494-Cell Line,
pubmed-meshheading:3036494-Cell Transformation, Neoplastic,
pubmed-meshheading:3036494-Genes,
pubmed-meshheading:3036494-Genes, Viral,
pubmed-meshheading:3036494-Hematopoietic Stem Cells,
pubmed-meshheading:3036494-Immunoglobulin M,
pubmed-meshheading:3036494-Leukemia Virus, Murine,
pubmed-meshheading:3036494-Mice,
pubmed-meshheading:3036494-Mice, Inbred BALB C,
pubmed-meshheading:3036494-Mutation,
pubmed-meshheading:3036494-Receptors, Antigen, B-Cell,
pubmed-meshheading:3036494-Temperature
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pubmed:year |
1987
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pubmed:articleTitle |
A temperature-sensitive mutant of Abelson murine leukemia virus confers inducibility of IgM expression to transformed lymphoid cells.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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