|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
1987-5-26
|
|
pubmed:abstractText |
Rat brain hippocampal slices were incubated with or without the convulsant 4-aminopyridine (4-AP). From these slices a crude mitochondrial/synaptosomal membrane fraction was prepared and analyzed for endogenous protein phosphorylation. 4-AP (10(-5) M) stimulated the phosphorylation of a 50 kDa protein by 86%. The phosphorylation of this 50 kDa protein is Ca2+/calmodulin-dependent and we suggest that this protein is the lower molecular weight subunit of Ca2+/calmodulin-dependent protein kinase II (CaMK II).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0006-8993
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
24
|
|
pubmed:volume |
404
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
345-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:3032338-4-Aminopyridine,
pubmed-meshheading:3032338-Aminopyridines,
pubmed-meshheading:3032338-Animals,
pubmed-meshheading:3032338-Calcium,
pubmed-meshheading:3032338-Calmodulin,
pubmed-meshheading:3032338-Hippocampus,
pubmed-meshheading:3032338-Male,
pubmed-meshheading:3032338-Nerve Tissue Proteins,
pubmed-meshheading:3032338-Phosphorylation,
pubmed-meshheading:3032338-Rats,
pubmed-meshheading:3032338-Rats, Inbred Strains,
pubmed-meshheading:3032338-Synaptosomes
|
|
pubmed:year |
1987
|
|
pubmed:articleTitle |
4-Aminopyridine affects synaptosomal protein phosphorylation in rat hippocampal slices.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
