Linked Life Data

3031698

Source:http://linkedlifedata.com/resource/pubmed/id/3031698

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1987-5-15
pubmed:abstractText
LTB4 is a potent chemotactic and chemokinetic eicosanoid released by leukocytes during inflammatory reaction; in addition to this it possesses a bronchopulmonary activity in different animal species. Since cysteinyl containing leukotrienes and other eicosanoids have been shown to induce hyperreactivity of pulmonary smooth muscles, we investigated the release of LTB4 from different anatomical structures of guinea-pig lung in vitro and the possible interaction with histamine in these tissues. In fact, hyperreactivity is evidentiated by a synergism between different mediators. The ovalbumin sensitized guinea-pig lung has been brushed in order to separate lung parenchyma from bronchi and vessels which were divided into large and small preparations. The antigen challenge resulted in a statistically significant increase in LTB4 production in large bronchi and vessels, whereas in the other preparations considered the basal levels of the eicosanoid were not modified during the anaphylactic reaction. In parallel with the differential site of LTB4 release, a positive interaction between LTB4 and histamine was only observed in the pulmonary artery. These data suggest that the possible role of LTB4 in different pulmonary diseases is not confined to the airway smooth muscle but it might be related to its capacity to induce vascular hyperreactivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0031-6989
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1139-49
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Differential release and effects of LTB4 in guinea-pig lung "in vitro".
pubmed:publicationType
Journal Article, In Vitro