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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1977-12-29
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pubmed:abstractText |
Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell-mediated immunity, which also may be genetically determined, played an important role in the expression of this disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1229-36
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:303145-Antibody Formation,
pubmed-meshheading:303145-Chromosome Aberrations,
pubmed-meshheading:303145-Colonic Neoplasms,
pubmed-meshheading:303145-Female,
pubmed-meshheading:303145-Humans,
pubmed-meshheading:303145-Hypersensitivity, Delayed,
pubmed-meshheading:303145-Lymphocyte Activation,
pubmed-meshheading:303145-Lymphoma,
pubmed-meshheading:303145-Male,
pubmed-meshheading:303145-Rosette Formation,
pubmed-meshheading:303145-T-Lymphocytes,
pubmed-meshheading:303145-Uterine Neoplasms
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pubmed:year |
1977
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pubmed:articleTitle |
Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies. II. Chromosomal and immunologic abnormalities.
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pubmed:publicationType |
Journal Article
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