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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1987-5-5
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pubmed:abstractText |
Biochemical and genetic analyses of the bacterium Salmonella typhimurium suggest that accumulation of alpha-ketobutyrate partially mediates the herbicidal activity of acetolactate synthase inhibitors. Growth inhibition of wild-type bacteria by the herbicide sulfometuron methyl was prevented by supplementing the medium with isoleucine, an allosteric inhibitor of threonine deaminase-catalyzed synthesis of alpha-ketobutyrate. In contrast, isoleucine did not rescue the growth of a mutant containing a threonine deaminase unresponsive to isoleucine. Moreover, the hypersensitivity of seven Tn10 insertion mutants to growth inhibition by sulfometuron methyl and alpha-ketobutyrate correlated with their inability to convert alpha-ketobutyrate to less noxious metabolites. We propose that alpha-ketobutyrate accumulation is an important component of sulfonylurea and imidazolinone herbicide action.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-16663712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-16663878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-17793381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-3003025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-354503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-362163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-368068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-3881312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-3894327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-3918815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-4585532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-6090425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-6185232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-6348482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-6369074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-6374157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-6378902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-6791581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-6805381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-6997277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-7007356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-7042686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-7548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3031008-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1372-8
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:3031008-Acetolactate Synthase,
pubmed-meshheading:3031008-Butyrates,
pubmed-meshheading:3031008-Butyric Acids,
pubmed-meshheading:3031008-DNA Transposable Elements,
pubmed-meshheading:3031008-Isoleucine,
pubmed-meshheading:3031008-Kinetics,
pubmed-meshheading:3031008-Mutation,
pubmed-meshheading:3031008-Oxo-Acid-Lyases,
pubmed-meshheading:3031008-Salmonella typhimurium,
pubmed-meshheading:3031008-Sulfonylurea Compounds,
pubmed-meshheading:3031008-Valine
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pubmed:year |
1987
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pubmed:articleTitle |
Toxic accumulation of alpha-ketobutyrate caused by inhibition of the branched-chain amino acid biosynthetic enzyme acetolactate synthase in Salmonella typhimurium.
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pubmed:publicationType |
Journal Article
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